NPTX2 Antilichaam

NPTX2 Antibody: Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.

4885

P47972

NP_002514

Human, Mouse, Rat

4573

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar NPTX2 expression profile in human and mouse cell lines detected by two independent anti-NPTX2 antibodies that recognize different epitopes, 4573 against central domain and 64-234 against another central domain. NPTX2 proteins are detected only in HeLa and HepG2 cell lines by the two independent antibodies. Independent Antibody Validation in Cell lines4573 64-234

Neuroscience

NPTX2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Guinea pig: (88%)

NPTX2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NPTX2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human NPTX2 has one isoform (431aa, 47kD) . Mouse NPTX2 has one isoform (429aa, 47.1kD) and Rat NPTX2 also has one isoform (432aa, 47.4kD) . 4573 can detect human, mouse and rat.

NPTX2

Cat. No. 1201 – HeLa Cell Lysate

Cat. No. 1211 – HepG2 Cell Lysate

Cat. No. 10-301 - Human Brain Tissue Slide

Neuronal pentraxin II

Homo sapiens

Hsu and Perin. Genomics1995; 28:220-7.

Tsu et al. J. Neurosci.1996; 16:2463-78.

Xu et al. Neuron2003; 39:513-28.

Moran et al. Acta Neuropathol.2008; 115:471-8.

NPTX2 Antibody: NP2, NARP, NP-II, Neuronal pentraxin-2, Neuronal pentraxin II, NP2

ELISA, WB, IHC-P, IF

28195384

Liquid