NRG1-beta 1-eiwit (EGF-domein, Fc-tag)

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

ARIA Protein; GGF Protein; GGF2 Protein; HGL Protein; HRG Protein; HRG1 Protein; HRGA Protein; MST131 Protein; MSTP131 Protein; NDF Protein; NRG1-IT2 Protein; SMDF Protein

Q02297-6

Human

Human

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 95 % as determined by SDS-PAGE

1. Measured by its binding ability in a functional ELISA. 2. Immobilized Rhesus ErbB3 at 2 μg/mL (100 μL/well) can bind human NRG1 (isoform Beta1) . The EC50 of human NRG1 (isoform Beta1) is 0.58 μg/mL. 3. Immobilized human ErbB3 at 2 μg/mL (100 μL/well) can bind human NRG1 (isoform Beta1) . The EC50 of human NRG1 (isoform Beta1) is 0.43 μg/mL. 4.Human breast cancer organoids were cultured with FGF7, RSPO1, IGF1, EGF, NRG1 Beta 1, NOG. 5.Human breast organoids were cultured with IGF1, NRG1 Beta 1. 6.Human ovarian organoids were cultured with IGF1, NRG1 Beta 1, RSPO1, EGF, NOG.

331

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

38 kDa (glycosylated monomer)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells