NRROS Proteïne, Muis, Recombinant (Hij)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable) .
Ice Packs
-20°C
Beschrijving
NRROS Proteïne, Muis, Recombinant (Hij) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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