NSMCE2 Antilichaam - middengebied: Biotine (ARP55690 P050-Biotine)

Non-SMC element 2, MMS21 homolog (S. cerevisiae)

NSE2, MMS21, ZMIZ7, C8orf36

286053

Q96MF7

NP_775956

Human, Mouse, Cow, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human NSMCE2

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

TXLNA; PAN2; UBC; NSMCE1; SMC6; PDS5A; SMC5; WAPAL; PDS5B; STAG2; SMC3; SMC1A; SUMO1; TSNAX; RAD21; ETV1; SUMO2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 79%; Rabbit: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

28kDa

Zandi, P.P., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2007) In press

Wet Ice

247

NSMCE2

NSMCE2

Rabbit

E3 SUMO-protein ligase NSE2

NM_173685

KFLALQSKNSDADFQNNEKFVQFKQQLKELKKQCGLQADREADGTEGVDE