NSP3 Polyklonale Antilichaam

Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2) . These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3) . The majority of TNF functions are primarily mediated through TNF-R1 (1,4) . FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5) . N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6) . FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5) .

Cas/HEF1 associated signal transducer; CHAT; FLJ39664; Novel SH2 containing protein 3; Novel SH2-containing protein 3; NSP 3; PRO34088; SH2 domain containing 3C; SH2 domain containing Eph receptor binding protein 1; SH2 domain containing protein 3C; SH2 domain-containing protein 3C; SH2D3_HUMAN; SH2D3C; Shep1.

Cytoplasm, Cell membrane

761-860/860

NSP3

Unconjugated

KLH conjugated synthetic peptide derived from human NSP3

WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Human, Mouse, Rat, Dog, Cow