NSUN2 Antilichaam - C-terminal regio : HRP (ARP48811_P050-HRP)

NOP2/Sun domain family, member 2

MISU, MRT5, SAKI, TRM4

54888

Q08J23

NP_060225

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human NSUN2

Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu (CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 is a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu (CAA) .Maturation of cytoplasmic tRNAs includes splicing of introns, which are located 1 nucleotide 3-prime from the anticodon in all intron-containing tRNA genes. In tRNA-leu (CAA), the first position of the anticodon, C34, is converted to 5-methylcytosine, a modification necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. NSUN2 encodes a methyltransferase that catalyzes the intron-dependent formation of 5-methylcytosine at C34 of tRNA-leu (CAA) (Brzezicha et al., 2006 [PubMed 17071714]) .[supplied by OMIM].

SUMO2; SUMO3; UBC; SUMO1; NEDD8; TP53RK; PUS1; EFTUD1; XPO5; UGGT1; OSGEP; PANK4; THG1L; SH3GLB1; KIAA1279; UBXN7; TTLL12; ARPC2; ACTR2; ACTR3; FUBP1; TSN; SH3GL1; RPA1; RDX; RANGAP1; PPP2CB; PFDN5; PFDN1; NRD1; PPP1R12A; HARS; GTF2E1; CALU; CALR; UBD; VC

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

86kDa

Huttenhofer, A., (2007) Mol. Biol. Cell 18 (3), 1107-1117

Wet Ice

767

NSUN2

NSUN2

Rabbit

TRNA (cytosine (34) -C (5) ) -methyltransferase

NM_017755

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