NT-3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues) . Human and Mouse NT-3 sequences are identical
NTF3; NT3; HDNF; NGF2; NGF-2
4908
P20783
NP_001096124.1
NM_001102654
12p13
Human
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
< 0.1 ng/µg of protein (< 1EU/µg)
> 98% by SDS-PAGE & HPLC analyses
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
120
Lyophilized
13.6 kDa
E. coli
Beschrijving
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume sta
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