NT-3

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues) . Human and Mouse NT-3 sequences are identical

NTF3; NT3; HDNF; NGF2; NGF-2

4908

P20783

NP_001096124.1

NM_001102654

12p13

Human

Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey

MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

120

Lyophilized

13.6 kDa

E. coli