Nuciferine

475-83-2

Sanjoinine E, (-) -Nuciferine, VLT 049

C09647-5mg

5-HT Receptor

Neuronal Signaling

CN1CCC2=CC (=C (C3=C2C1CC4=CC=CC=C43) OC) OC

C19H21NO2

Nuciferine (Sanjoinine E, (-) -Nuciferine, VLT 049) is a major active aporphine alkaloid from the leaves of N. nucifera Gaertn and possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

2 years -80 in solvent