NUDT1 Antilichaam, KO gevalideerd

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

4521

P36639

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Other

Affinity purification

SW480

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 18kDa

IgG

NUDT1

K562

22RV1

THP-1

HepG2

SKOV3

Nudix hydrolase 1

Homo sapiens

MTH1, 7,8-dihydro-8-oxoguanine triphosphatase, 2-hydroxy-dATP diphosphatase, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, 8-oxo-7,8-dihydroguanosine triphosphatase, 8-oxo-dGTPase, mutT human homolog 1, nucleoside diphosphate-linked moiety X motif 1, nucleoside diphosphate-linked moiety X-type motif 1, nudix (nucleoside diphosphate linked moiety X) -type motif 1, nudix motif 1

WB, IHC, IP

Liquid