NUMA1 Antilichaam - C-terminal regio : HRP (ARP50532 P050-HRP)

Nuclear mitotic apparatus protein 1

NUMA, NMP-22

4926

Q14980

NP_006176

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1

NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.

CCDC57; GMCL1; BRAP; DVL3; DVL2; DVL1; UBC; LGR4; ERG; RPA3; RPA2; RPA1; RNF2; EZH2; BMI1; SUZ12; EED; YWHAQ; LMNA; CBX6; WHSC1; HSP90AB1; HSP90AA1; ESR1; CDK6; VCP; SMURF1; MDC1; TP53BP1; ECT2; NCSTN; DDB1; EMILIN1; DYNLL1; RAE1; NUP98; CDK2; TERF2IP; TE

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

238kDa

Kilpivaara, O., (er) BMC Cancer 8, 71 (2008)

Wet Ice

2115

NUMA1

NUMA1

Rabbit

Nuclear mitotic apparatus protein 1

NM_006185

AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL