Numb Antilichaam

NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.

8650

P49757

NP_1005743

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

NUMB Antibody is affinity chromatography purified via peptide column.

Cat. No. 1402 - Mouse Lung Tissue Lysate

1 mg/mL

NUMB Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NUMB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of NUMB are known to exist; this antibody will detect all of them.

NUMB

Cat. No. 10-101 - Human Lung Tissue Slide

Numb homolog (Drosophila)

Homo sapiens

Zhong W, Feder JN, Jiang MM, et al. Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron 1996; 17:43-53.

Wu M, Kwon HY, Rattis F, et al. Imaging hematopoietic precursor division in real time. Cell. Stem Cell 2007; 1:541-54.

Conboy IM and Rando TA. The regulation of Notch signaling controls satellite cell activation, cell fate determination in postnatal myogenesis. Dev. Cell 2002; 3:397-409

Yogosawa S, Miyauchi Y, Honda R, et al. Mammalian Numb is a target protein of Mdm2, ubiquitin ligase. Biochem. Biophys. Res. Commun. 2003; 302:869-72.

NUMB Antibody: S171, C14orf41, c14_5527, Protein numb homolog, Protein S171, h-Numb

ELISA, WB, IHC-P, IF

54144625

Liquid