NUP155 Antilichaam

NUP155 Antibody: The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. One protein in this assembly is the nucleoporin (NUP) -155, which is localized symmetrically to both the nucleoplasmic and cytoplasmic faces of the NPC. NUP155 has been reported to interact with both NUP35 and the mRNA export factor Gle1, but the functions of these interactions are still unknown. NUP155 has also been shown to be required for NPC assembly and nuclear envelope (NE) membrane fusion. NUP155 is recruited late in NE formation, suggesting that NUP155 defines an essential late step in NE assembly. NUP155 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP155 may be an important drug target in HIV treatment. At least two isoforms of NUP155 are known to exist.

9631

O75694

NP_705618

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

NUP155 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1286 - P815 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (100%)

NUP155 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

NUP155 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

NUP155

Nucleoporin 155kDa

Homo sapiens

Tran EJ and Wente SR. Dynamic nuclear pore complex: life on the edge. Cell2006; 125:1041-53.

Radu A, Blobel G and Wozniak RW. Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA. J. Cell Biol.1993; 121:1-9.

Hawryluk-Gara LA, Shibuya EK, and Wozniak RW. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol. Biol. Cell2005; 16:2382-94.

Rayala HJ, Kendirgi F, Barry DM, et al. The mRNA export factor Gle1 interacts with the nuclear pore complex protein Nup155. Mol. Cell Proteomics2004; 3:145-55.

NUP155 Antibody: N155, KIAA0791, Nuclear pore complex protein Nup155, 155 kDa nucleoporin

ELISA, WB

24430149

Liquid