Nusinersen
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1258984-36-9
C15163-1mg
DNA/RNA Synthesis
Cell Cycle
Nusinersen is an 18-mer, 2′-O- (2-methoxyethyl) phosphorothioate antisense oligonucleotide used for treating spinal muscular atrophy (SMA) . It binds specifically to the intronic splice silencer N1 (ISS-N1) site in intron 7 of SMN2 pre-mRNA, blocking the binding of splicing repressors hnRNP A1/A2. This promotes inclusion of exon 7 during splicing, restoring full-length SMN protein production in SMA patients.
Beschrijving
Nusinersen Beschikbaar in 1 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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