NVP-2
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
NVP-2 is a highly selective and potent (IC50 = 0.514 nM) inhibitor of cyclin dependent kinase 9 (CDK9) .1 It inhibited proliferation of MOLT4 cells (IC50 = 9 nM) . Treatment of cells with NVP-2 resulted in profound downregulation of core regulatory circuitry genes. It has also been shown to be a potent inhibitor of CDK10 (IC50 = 29 nM; this study gives an IC50 of 6 nM for CDK9) .2 NVP-2 acted synergistically with orlistat to inhibit acute myeloid leukemia cells (IC50s: Kasumi-1 cells 7.58 nM; U937 cells 8.99 nM) .3
Unconjugated
Off-white to beige solid
-20°C
Beschrijving
NVP-2 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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