NVP-231
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Reversible inhibitor of ceramide kinase (IC50 = 12 nM) .1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
Unconjugated
White solid
-20°C
Beschrijving
NVP-231 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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