O-Desmethylmidostarine-13C6

O-Desmethyl midostaurin-13C6 (CGP62221-13C6; O-Desmethyl PKC412-13C6) is the 13C-labeled O-Desmethyl Midostaurin. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.

CGP62221-13C6; O-Desmethyl PKC412-13C6

12352005

Isotope-Labeled Compounds; PKC

Epigenetics; Others; TGF-beta/Smad

Cancer

O[C@@H]1[C@@H](C[C@H]2O[C@@]1(N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5CNC8=O)C=CC=C4)C)N(C)C([13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9)=O

C28 13C6H28N4O4

562.57

[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108 (10) :3477-83.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W751181/

Isotope-Labeled Compounds

No Development Reported