O6-Benzylguanine (standaard)

O6-Benzylguanine, a guanine analog, is the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (MGMT/AGT) inhibitor. O6-Benzylguanine acts as an AGT substrate, which transfers its benzyl group to the AGT cysteine residue, thereby irreversibly inactivating AGT and preventing DNA repair. O6-Benzylguanine induces tumor cell apoptosis. Antineoplastic activity[1][2].

19916-73-5

12352005

Apoptosis; DNA/RNA Synthesis

Apoptosis; Cell Cycle/DNA Damage

Cancer

NC(N=C1OCC2=CC=CC=C2)=NC3=C1NC=N3

C12H11N5O

241.25

[1]Rabik CA, Njoku MC, Dolan ME. Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat Rev. 2006;32 (4) :261‐276.|[2]Konduri, Santhi D et al. Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 15,19 (2009) : 6087-95.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W002585R/

Reference Standards