OAS1 Antilichaam - C-terminaal gebied: Biotine (ARP51360 P050-Biotine)

2'-5'-oligoadenylate synthetase 1, 40/46kDa

OIAS, IFI-4, OIASI, E18/E16

4938

P00973-2

NP_002525

Human

The immunogen is a synthetic peptide directed towards the C terminal region of human OAS1

OAS1 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Mutations in this gene have been associated with host susceptibility to viral infection.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

EXOC5; TRIM27; ACTN1; PRMT6; WBSCR22; RPL30; HCVgp1

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

42kDa

Phosri, C., Mycol. Res. 111 (PT 3), 275-286 (2007)

Wet Ice

364

OAS1

OAS1

Rabbit

2'-5'-oligoadenylate synthase 1

NM_002534

GWRQLAQEAEAWLNYPCFKNWDGSPVSSWILLVRPPASSLPFIPAPLHEA