Octamethylcyclotetradiamine

Octamethylcyclotetrasiloxane promotes the anchorage-independent growth of MCF-10A and MCF-10F cells. Octamethylcyclotetrasiloxane induces DNA damage, inhibits the expression of DNA-repairing protein BRCA1 under long-term and high-concentration exposure. Octamethylcyclotetrasiloxane exhibits intrinsic estrogenic activity[1].

556-67-2

12352005

H226, H361, H410

DNA/RNA Synthesis

Cell Cycle/DNA Damage

Metabolism-protein/nucleotide metabolism

Endocrinology

99.86

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1

C8H24O4Si4

296.62

H226, H361, H410

[1]Farasani A, et al., Exposure to cyclic volatile methylsiloxanes (cVMS) causes anchorage-independent growth and reduction of BRCA1 in non-transformed human breast epithelial cells. J Appl Toxicol. 2017 Apr;37 (4) :454-461.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W116007/Octamethylcyclotetrasiloxane-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported