Octreotide-d8 (acetaat)

Octreotide-d8 (acetate) (SMS 201-995-d8 (acetate) ) is deuterium labeled Octreotide. Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

SMS 201-995-d8 (acetate)

12352211

Isotope-Labeled Compounds

Others

Metabolism-protein/nucleotide metabolism

Cancer; Endocrinology; Inflammation/Immunology; Cardiovascular Disease

O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(NC(CO)C(O)C)=O)NC(C(N)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)=O)CC3=CC=CC=C3)N[C@H]1CC4=CNC5=CC=CC=C45.CC(O)=O

C51H62D8N10O12S2

1087.34

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P0036S4/

Isotope-Labeled Compounds

No Development Reported