Octreotide (dihydrochloride)

Octreotide (SMS 201-995) hydrochloride is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide hydrochloride can bind to the somatostatin receptors which are mainly subtypes 2, 3 and 5. Octreotide hydrochloride increases Gi activity and reduces intracellular cAMP production. Octreotide hydrochloride has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2].

1607842-55-6

SMS 201-995 (dihydrochloride)

12352209

Apoptosis; Somatostatin Receptor

Apoptosis; GPCR/G Protein; Neuronal Signaling

Cancer; Endocrinology; Inflammation/Immunology

10 mM in DMSO

O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@H](CO)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45.Cl.Cl

C49H68Cl2N10O10S2

1092.16

[1]Octreotide pamoate, OncoLAR, OP-LAR|[2]Chand Khanna, et al. A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy. Clin Cancer Res. 2002 Jul;8 (7) :2406-12.|[3]Xiao-Xia Wang, et al. Effects of octreotide on hepatic glycogenesis in rats with high fat diet‑induced obesity. Mol Med Rep. 2017 Jul;16 (1) :109-118.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P0036A/

Peptides

No Development Reported