OGG1 Antilichaam

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

4968

O15527

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-345 of human OGG1 (NP_002533.1) .

Unconjugated

Primary Antibodies

Cancer

Affinity purification

Mouse heart

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 36kDa

IgG

OGG1

Rat heart

N-glycosylase/DNA lyase

Homo sapiens

N-glycosylase/DNA lyase, 8-oxoguanine DNA glycosylase, 322-, DNA- (apurinic or apyrimidinic site) lyase, AP lyase, OGG1, MMH, MUTM, OGH1

WB, IHC

Liquid