OGT Antilichaam - N-terminaal gebied: Biotine (ARP49154_P050-Biotine)

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

OGT1, HRNT1, MRX106, HINCUT-1, O-GLCNAC

8473

O15294

NP_858058

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human OGT

OGT catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains nine tetratricopeptide repeats and a putative bipartite nuclear localization signal. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

FBXW11; HUWE1; UBC; PSG1; PHC3; NUP62CL; TET2; SUMO1; NEDD8; WWOX; BAP1; P3H1; RPRD1B; PPME1; LAP3; DBNL; HSPBP1; GPN1; WDR4; ACTR2; TOM1L1; ZPR1; SURF2; LPP; AGFG1; ALAD; C14orf142; UBL4A; FOXO4; HCFC1; SMURF1; Hoxa1; Nfatc1; Nup62; RELA; PPP1CB; PPP1CA

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

OGT is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

117kDa

Taylor, R.P., (2008) J. Biol. Chem. 283 (10), 6050-6057

Wet Ice

1046

OGT

OGT

Rabbit

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

NM_181672

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