Ohchinolide B
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Ohchinolide B is a tubulin inhibitor. Ohchinolide B inhibits microtubule polymerization (IC50=2.3 μM) and induces G2/M phase cell cycle arrest via mitochondrial apoptotic pathways. Ohchinolide B is promising for research of solid tumors (e.g., breast, lung cancer) [1].
71902-49-3
12352005
Microtubule/Tubulin
Cell Cycle/DNA Damage; Cytoskeleton
Cancer-programmed cell death
Cancer
C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(C)=O)OC(C)=O)C)([H])[C@H]([C@@]4([C@]1([H])CC(O[C@]5([H])C4=C([C@H](C6=COC=C6)C5)C)=O)C)OC(/C(C)=C/C)=O
C35H44O10
624.72
[1]Ochi M, et al. The structures of ohchinolide A and B, two new limonoids from Melia azedarach Linn. var. japonica Makino[J]. Chemistry Letters, 1979, 8 (9) : 1137-1140.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-N12331/
Natural Products
No Development Reported
Beschrijving
Ohchinolide B is a tubulin inhibitor. Ohchinolide B inhibits microtubule polymerization (IC50=2.3 μM) and induces G2/M phase cell cycle arrest via mitochondrial
Specificaties
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