OLIG2 Antilichaam

The oligodendrocyte transcription factors 1 and 2 (OLIG1 and OLIG2, respectively) make up part of basic helix-loop-helix (bHLH) family of transcription factors that are specifically expressed in zones of the neuroepithelium from which oligodendrocyte precursors emerge (1) . Both OLIG1 and OLIG2 genes are downstream targets of Sonic hedgehog and are expressed exclusively in the central nervous system (2) . OLIG2 is first observed in the ventral most p3 progenitor domain of the ventral neural tube while OLIG1 is first expressed in the dorsal portion of the p3 domain (2) . Mice overexpressing OLIG2 exhibit impaired potassium channel expression in neural progenitors and proliferation of these cells similar to that seen in Down Syndrome, suggesting that OLIG2 may play a role in this pathology (3) .

10215

Q13516

NP_005797

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

OLIG2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

OLIG2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

OLIG2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

OLIG2 antibody is human, mouse and rat reactive. It is predicted to not cross-react with other members of the OLIG family of proteins. At least three isoforms of OLIG2 are known to exist; this antibody will detect all three isoforms.

OLIG2

Oligodendrocyte lineage transcription factor 2

Homo sapiens

Zhou Q, Wang S, and Anderson DJ. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron 2000; 25:331-43.

Lu QR, Yuk D, Alberta JA, et al. Sonic Hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 2000; 25:317-29.

Lu J, Lian G, Zhou H, et al. OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors. Hum. Mol. Genet. 2012; 21:2330-40.

OLIG2 Antibody: BHLHB1, OLIGO2, RACK17, PRKCBP2, bHLHe19, BHLHB1, BHLHE19, Oligodendrocyte transcription factor 2, Class B basic helix-loop-helix protein 1, Oligo2

ELISA, WB, IHC-P, IF

17978475

Liquid