Ompenaclid (Standaard)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2].
353-09-3
12352211
Apoptosis; Endogenous Metabolite
Apoptosis; Metabolic Enzyme/Protease
Cancer
O=C(O)CCNC(N)=N
C4H9N3O2
131.14
[1]Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8;7 (41) :eabi7511.|[2]Creisméas A, et, al. TRPC1 and TRPC3 involvement in DMD physiopathology and as potential targets for treatment in complement to rAAV-microdystrophin. 2021 Oct 1;13.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W015828R/
Reference Standards
Beschrijving
Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracel
Specificaties
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