Onderzoeksgraad MEDI3185

MEDI3185haspicomolarbindingaffinitytohumanCXCR4andexhibitsnosignificantbindingtootherchemokinereceptorssuchasCCR4orCXCR3.InvitrostudiesdemonstratedthatMEDI3185inhibitedtumorcellmigration, blockedSDF-1inducedtumorcellsignalingandinducedapoptosisoftumorcells.TheMEDI3185epitopecomprisestheentireECL2sequence, lacksanyso-called'hot-spot'andisremarkablyresistanttomutations.ThestructureofMEDI3185variabledomainswasmodeled, andsuggestedaβ-strand/β-strandinteractionbetweenMEDI3185CDR3HandCXCR4ECL2, resultingindirectsterichindrancewithCXCR4ligandSDF-1.

Mammalian Cells

Stromalcell-derivedfactor1receptor, LCR1, HM89, LPS-associatedprotein3, LAP-3, CXC-R4, CXCR-4, SDF-1receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-Cchemokinereceptortype4, CXCR4, Lipopolysaccharide-associatedprotein3, Leukocyte-derivedseventransmembranedomainreceptor

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Protein A/G purified from cell culture supernatant.

1mg/ml

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Liquid

0.01M PBS, pH7.4.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at4°C short term (1-2weeks) . Store at-20°C 12 months. Store at -820°C long term.

For research use only. Not suitable for clinical or therapeutic use.

0.01M PBS, pH7.4.

Human

IgG1