Onderzoeksklasse Ulocuplumab

Ulocuplumab (BMS-936564) isafirst-in-classfullyhumanIgG4monoclonalanti-CXCR4antibodythatinhibitsthebindingofCXCR4toCXCL12.TheCXCR4/CXCL12 (SDF-1) axishasbeenknownformanyyearsasacriticalregulatoroftumorproliferation, cell, aswellasmigrationintoandoutofthebonemarrow.

BMS-936564, MDX-1338, MDX1338, CAS:1375830-34-4

Mammalian Cells

Stromalcell-derivedfactor1receptor, LCR1, HM89, LPS-associatedprotein3, LAP-3, CXC-R4, CXCR-4, SDF-1receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-Cchemokinereceptortype4, CXCR4, Lipopolysaccharide-associatedprotein3, Leukocyte-derivedseventransmembranedomainreceptor

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Protein A/G purified from cell culture supernatant.

1.59mg/ml

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Liquid

0.01M PBS, pH7.4.

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at4°C short term (1-2weeks) . Store at-20°C 12 months. Store at -285°C long term.

For research use only. Not suitable for clinical or therapeutic use.

0.01M PBS, pH7.4.

Human

IgG4-kappa