Op18 Antilichaam

Op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.

3925

P16949

AAH82228

Human, Mouse, Rat

4237

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar op18 expression profile in human, mouse and rat cell lines detected by two independent anti-op18 antibodies that recognize different epitopes, 4235 against C-terminus domain and 4237 against N-terminus domain. op18 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4235 4237

Homeostasis

Op18 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (88%)

Op18 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Op18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human op18 has 2 isoforms, including isoform 1 (149aa, 17kD) and isoform 2 (174aa, 20kD) . Mouse op18 has one isoform (149aa, 17kD) and Rat op18 also has one isoform (149aa, 17kD) . 4237 can detect all isoforms of human, mouse and rat.

STMN1

Cat. No. 10-301 - Human Brain Tissue Slide

STMN1

Homo sapiens

Curmi et al. Cell Structure and Function 1999; 24:345-57.

Belmont et al. Cell 1996; 84:623-31.

Mizumura et al. J. Cell Physiol. 2006; 206:363-70.

Mistry et al. Mount Sinai J. Med. 2002; 69:299-304.

Op18 Antibody: Lag, SMN, OP18, PP17, PP19, PR22, LAP18, C1orf215, Stathmin, Leukemia-associated phosphoprotein p18, Op18

ELISA, WB, IHC-P, IF

51895905

Liquid