OPTN Antilichaam - N-terminalgebied: HRP (ARP39525_P050-HRP)

Optineurin

NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP

10133

Q96CV9

NP_001008214

Human, Rat, Cow, Dog, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the N terminal region of human OPTN

OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

RAB10; TNIP1; OPTN; DAZAP2; CDC23; UBC; PARK2; ZNF670; ZNF329; TBC1D15; ZNF398; CCDC53; MAP1LC3A; TBC1D17; HACE1; RAB25; RAB11B; SQSTM1; RAB11A; Rab8a; Tfrc; BRE; FAM178A; UQCRQ; GNAS; RAB12; EPS15; RAB14; MAP1LC3B; PIAS4; RNF11; RIPK1; TNFRSF1A; TNF; HTT

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 83%; Guinea Pig: 79%; Horse: 86%; Human: 100%; Rat: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

66kDa

Morton, S., (2008) FEBS Lett. 582 (6), 997-1002

Wet Ice

577

OPTN

OPTN

Rabbit

Optineurin

NM_001008213

SHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTEN