ORAI1 Antilichaam

ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.

84876

Q96D31

Q96D31

Human, Mouse

Unconjugated

Primary Antibodies

Immunology

ORAI1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (93%), Chicken: (100%)

ORAI1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ORAI1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

ORAI1

Cat. No. 11-201 - Human Ovary Tissue Slide

Cat. No. 10-901 - Human Spleen Tissue Slide

ORAI calcium release-activated calcium modulator 1

Homo sapiens

Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol.2001; 19:497-521.

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature2006; 441:179-85.

Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta.2006; 1763:1161-8.

ORAI1 Antibody: IMD9, ORAT1, CRACM1, TMEM142A, Calcium release-activated calcium channel protein 1, Protein orai-1

ELISA, WB, IHC-P, IF

97180269

Liquid