ORAI1 Antilichaam [3F6H5]

ORAI1 Monoclonal Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

84876

Q96D31

Q96D31

Human, Mouse, Rat

Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.

3F6H5

Unconjugated

Primary Antibodies

Immunology

ORAI1 Monoclonal Antibody is Protein A purified.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ORAI1 monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG1

ORAI1 antibody is predicted to have no cross reactivity to other members in the ORAI family.

ORAI1

Cat. No. 10-901 - Human Spleen Tissue Slide

ORAI calcium release-activated calcium modulator 1

Homo sapiens

Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.

Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.

ORAI1 Antibody [3F6H5] : IMD9, ORAT1, CRACM1, TMEM142A

ELISA, WB, IHC-P, IF

97180269

Liquid