ORIC-101

ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

2222344-98-9

12352005

Glucocorticoid Receptor

Reference compound

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Metabolism-sugar/lipid metabolism

Cancer; Endocrinology

https://www.medchemexpress.com/ORIC-101.html

10mM

99.30

DMSO : ≥ 100 mg/mL

CN(C(C)C)C1=CC=C([C@@H]2[C@@]([C@](CC3)([H])C(CC4)=CC3=O)([H])[C@]4([H])[C@@](CC[C@]5(C#CC(C)(C)C)O)([H])[C@]5(C)C2)C=C1

C34H47NO2

501.74

[1]Rew Y, et al. Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101) . J Med Chem. 2018 Sep 13;61 (17) :7767-7784.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-112710/ORIC-101-SDS-MedChemExpress.pdf

Reference compound1

Phase 1