ORMDL1 Antilichaam

ORMDL1 Antibody: The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD) . Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

94101

Q9P0S3

NP_057551

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

ORMDL1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (94%)

ORMDL1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ORMDL1 antibody can be stored at 4 ˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ORMDL1 antibody may cross-react with other ORMDL protein family members.

ORMDL1

ORM1-like 1 (S. cerevisiae)

Homo sapiens

Hjelmqvist L, Tuson M, Marfany G, et al. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol. 2002; 3 (6) : RESEARCH0027

Araki W, Takahashi-Sasaki N, Chui DH, et al. A family of membrane proteins associated with Presenilin expression and α -secretase function. FASEB J. 2007; 22: 819-827

Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448: 470-473

Breslow DK, Collins SR, Bodenmiller B, et al. Orm family proteins mediate sphingolipid homeostasis. Nature. 2010; 463 (7284) :1048-53

ORMDL1 Antibody: ORM1-like protein 1, Adoplin-1

ELISA, WB, IHC-P, IF

189458852

Liquid