OSS-128167
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 µM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 µM, respectively) .1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5
Unconjugated
Off-white solid
-20°C
Beschrijving
OSS-128167 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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