OTX2 Antilichaam

This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6) . This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

5015

P32243

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human OTX2 (NP_068374.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience, Stem Cell, Transcription

Affinity purification

A673

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 37kDa

IgG

OTX2

Orthodenticle homeobox 2

Homo sapiens

OTX2, MCOPS5, MGC45000, CPHD6

WB, IHC, IF

Liquid