OX-40L / TNFSF4 / CD252 Proteïne (ECD, hFc-tag)

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

CD134L Protein; CD252 Protein; GP34 Protein; OX-40L Protein; OX4OL Protein; TNLG2B Protein; TXGP1 Protein

NP_003317.1

Human

Human

HFc-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 95 % as determined by SDS-PAGE.

1.Loaded Recombinant Human OX40 Ligand/TNFSF4 Protein, hFc Tag on ProA Biosensor, can bind Recombinant Human OX40/TNFRSF4 Protein, His Tag with an affinity constant of 0.909 μM as determined in BLI assay (Sartorius Octet RED384) . 2.Immobilized Recombinant Human OX40 Protein (His & AVI Tag), Biotinylated at 1 μg/mL (100 μL/well) on streptavidin precoated (5 μg/mL, 100 μL/well) plate can bind Recombinant Human OX-40L / TNFSF4 / CD252 Protein (ECD, Fc Tag) . The EC50 is 2.0-6.0 ng/mL.

412

Lyophilized

PBS, pH 7.4

See Datasheet

47 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells