OX40L / TNFSFSF4 eiwit (ECD, zijn label)

OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX40. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD4-stimulated B cells, this cytokine along with CD7 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.

Ath-1 Protein; Ath1 Protein; CD134L Protein; gp34 Protein; OX-40L Protein; Ox40l Protein; Tnfsf4 Protein; Tnlg2b Protein; TXGP1 Protein; Txgp1l Protein

NP_033478.1

Mouse

Mouse

His-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 95 % as determined by SDS-PAGE.

1.Measured by its binding ability in a functional ELISA. Immobilized TNFSF4 Protein, Mouse, (ECD, His Tag) at 2 μg/mL (100 μL/well) can bind OX40 , Human, the EC50 of OX40 is 30-90 ng/mL. 2. Immobilized Recombinant Mouse OX40L / TNFSF4 Protein (ECD, His Tag) at 0.5 μg/mL (100 μL/well) can bind Recombinant Human OX40 / CD134 Protein (Fc Tag), the EC50 is 3.8-11.4 ng/mL.

159

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

18 kDa

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells