Oxaminezuur (standaard)

Oxamic acid (Standard) is the analytical standard of Oxamic acid. This product is intended for research and analytical applications. Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

471-47-6

Oxamidic acid (Standard)

12352211

Apoptosis; Lactate Dehydrogenase; Reference Standards

Apoptosis; Metabolic Enzyme/Protease; Others

Cancer

NC(C(O)=O)=O

C2H3NO3

89.05

[1]Xiang J, et al. LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells. Aging (Albany NY) . 2021 Dec 16;13 (24) :25920-25930.|[2]Zhai X, et al. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 2013 Dec;30 (6) :2983-91.|[3]Muramatsu H, et al. Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells. Oncol Rep. 2019 Jul;42 (1) :224-230.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W013032R/

Reference Standards