Oxaprozin-d10

Oxaprozin-d10 (Oxaprozinum-d10; Wy21743-d10) is the deuterium labeled Oxaprozin. Oxaprozin is an orally active and potent COX inhibitor, with IC50 values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB pathway contributes to its anti-inflammatory properties[1][2].

Oxaprozinum-d10; Wy21743-d10

12352005

Akt; Apoptosis; COX; IKK; Isotope-Labeled Compounds; NF-κB

Apoptosis; Immunology/Inflammation; NF-κB; Others; PI3K/Akt/mTOR

COVID-19-immunoregulation

Inflammation/Immunology

[2H]C1=C(C([2H])=C(C([2H])=C1C2=C(OC(CCC(O)=O)=N2)C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[2H])[2H]

C18H5D10NO3

303.38

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W709448/

Isotope-Labeled Compounds

No Development Reported