Oxeladin

Oxeladin is an orally active and brain-penetrant cough suppressant as well as a selective sigma 1 receptor agonist (Ki = 25 nM) . Oxeladin can be used for pulmonary diseases and stroke research[1][2].

468-61-1

12352005

H301-H311-H331

Sigma Receptor

Neuronal Signaling

Neurological Disease; Cardiovascular Disease; Inflammation/Immunology

O=C(OCCOCCN(CC)CC)C(CC)(CC)C1=CC=CC=C1

C20H33NO3

335.48

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

[1]Schreihofer DA, et al. Treatment of Stroke at a Delayed Timepoint with a Repurposed Drug Targeting Sigma 1 Receptors. Transl Stroke Res. 2023. Epub ahead of print. |[2]Dalwadi DA, et al. Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands. J Pharmacol Toxicol Methods. 2022;113:107129.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1216A/

Reference compound1

Launched

Sigma 1 Receptor