Oxybenzon-13C6

Oxybenzone-13C6 (Benzophenone 3-13C6) is the 13C-labeled Oxybenzone. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[1][2][3].

Benzophenone 3-13C6

12352005

Apoptosis; Autophagy; Isotope-Labeled Compounds; RAR/RXR

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Neuroscience-Neurodegeneration

Neurological Disease

O=C(C1=CC=C(OC)C=C1O)[13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2

C8 13C6H12O3

234.20

[1]Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118. |[2]DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 2019;86:98-100.|[3]Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55 (6) :5059-5074.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0067S1/

Isotope-Labeled Compounds

No Development Reported