Oxybenzon-d3

Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium labeled Oxybenzone. Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[1][2][3].

Benzophenone 3-d3

12352005

Apoptosis; Autophagy; Isotope-Labeled Compounds; RAR/RXR

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Neurological Disease

O=C(C1=C(C=C(C=C1)OC([2H])([2H])[2H])O)C2=CC=CC=C2

C14H9D3O3

231.26

[1]Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.|[2]DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease. Reprod Toxicol. 2019;86:98-100.|[3]Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55 (6) :5059-5074.|[4]Ying Zhang, et al. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59 (3) :191-200. |[5]Songbo Fu, et al. Matrine induces papillary thyroid cancer cell apoptosis in vitro and suppresses tumor growth in vivo by downregulating miR-182-5p. Biomed Pharmacother. 2020 Aug;128:110327. |[6]Bei Zhao, et al. Matrine suppresses lung cancer metastasis via targeting M2-like tumour-associated-macrophages polarization. Am J Cancer Res. 2021 Sep 15;11 (9) :4308-4328. |[7]Lu Yuan, et al. Matrine alleviates cisplatin‐induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway. J Cell Mol Med v.26 (13) ; 2022 Jul.|[8]Runjie Wei, et al. Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways. Cell Stress Chaperones. 2018 Nov;23 (6) :1295-1309.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W653958/

Isotope-Labeled Compounds

No Development Reported