P130 Cas (fosfo Tyr410) Antilichaam

Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

9564

P56945

NP_055382.2

Human, Mouse, Rat

P130 Cas (phospho Tyr410) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 410 (G-V-Y (p) -A-V) derived from Human p130 Cas .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

130 kDa

IgG

The antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 410.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

BCAR1

Breast cancer anti-estrogen resistance 1

Homo sapiens

Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.

Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.

Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.

Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6

BCAR1, CRKAS, CRK-ASSOCIATED SUBSTRATE

WB, IHC

44662836

Liquid