P15 INK4b (CDKN2B) Mouse Monoclonal Antibody [Kloon ID: LBI8H4]

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]

Carrier-free (BSA/glycerol-free) CDKN2B mouse monoclonal antibody, clone LBI8H4

CDK4I; INK4B; MTS2; P15; p15INK4b; TP15

Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B), transcript variant 1, mRNA.

1030

P42772

Unconjugated

Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway

WB 1:500~2000, IHC 1:150, IF 1:100

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CDKN2B

https://www.ncbi.nlm.nih.gov/gene/?term=1030

https://www.uniprot.org/uniprot/P42772