P150 CAF1 Polyklonale Antilichaam, HRP-vervoeging

Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity) . The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

CAF-1 p150; CAF 1 150 kDa subunit; CAF 1; CAF 1 subunit A; CAF; CAF I 150 kDa subunit; CAF I p150; CAF Ip150; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF1 150 kDa subunit; CAF1; CAF1 p150 Subunit; CAF1 subunit A; CAF1A; CAF1A; CAF1A_HUMAN; CAF1B; CAF1P150; CAF1P155; CAF1P155; CHAF1A; Chromatin assembly factor 1 subunit A; Chromatin Assembly Factor 1 Subunit A p150; Chromatin assembly factor I 150 kDa; Chromatin assembly factor I 150 kDa; Chromatin Assembly Factor I; Chromatin assembly factor I p150 subunit; DCAF1; hp150; Nucleosome Remodeling Factor 150kDa Subunit; NURF150; P150.

10036

Mouse

355-450/956

P150 CAF1

HRP

KLH conjugated synthetic peptide derived from human p150 CAF1

WB, IHC-P

Purified by Protein A.

1µg/µl

WB (1:300-5000), IHC-P (1:200-400)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

10036

Human, Rat, Dog, Cow, Pig, Horse