P2RX7 Antilichaam

The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1) . This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2) . Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2) . Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4) .

5027

Q99572

NP_002553

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction, Immunology

P2RX7 antibody is affinity chromatography purified via peptide column.

Cat. No. 1212 - 3T3 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (81%)

P2RX7 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

P2RX7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

P2RX7 antibody is human, mouse, and rat reactive. Multiple isoforms of P2RX7 are known to exist.

P2RX7

Cat. No. 17-201 - 3T3/BALB Cell Slide

Purinergic receptor P2X, ligand-gated ion channel, 7

Homo sapiens

Surprenant A, Rassendren F, Kawashima E, et al. The cytosolic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7) . Science 1996; 272:735-8.

North RA. Molecular physiology of P2X receptors. Physiol. Rev. 2002; 82:1013-67.

Labasi JM, Petrushova N, Donovan C, et al. Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J. Immunol. 168:6436-45.

Basso AM, Bratcher NA, Harris RR, et al. Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety; relevance for neuropsychiatric disorders. Behav. Brain Res. 2009; 198:83-90.

P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7

ELISA, WB, ICC, IF

300068987

Liquid