P47/Pleckstrin Polyklonale Antilichaam, HRP-vervoeging
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Platelet P47, also known as NSFL1C, UBX1, UBXD10 or UBXN2C, is a 370 amino acid protein that localizes to both the nucleus and the golgi apparatus (specifically to golgi stacks) and contains one SEP domain and one UBX domain. Functioning as part of a ternary complex with VCP (a protein involved in the heterotypic fusion of transport vesicles with their target membranes) and Syntaxin 5, p47 interacts with and reduces the ATPase activity of VCP and is required for the fragmentation of golgi stacks during mitosis and for subsequent reassembly of golgi stacks after mitosis. p47 is subject to phosphorylation during mitosis, which inhibits p47-golgi interaction and is, therefore, required for proper golgi stack formation and cisternal regrowth. Human p47 shares 89% sequence identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of p47 exist due to alternative splicing events.
P47; Platelet 47 kDa protein; Platelet and leukocyte C kinase substrate; Platelet P47; Platelet p47 protein; Pleckstrin; PLEK; PLEK_HUMAN; FLJ27168; OTTHUMP00000159962.
5341
• Rabbit
Human, Mouse, Rat
21-120/350
P47/Pleckstrin
• Polyclonal
• IgG
HRP
KLH conjugated synthetic peptide derived from human Pleckstrin/p47
WB, IHC-P, IHC-F
Purified by Protein A.
1µg/µl
WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500)
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Unmodified
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
5341
Beschrijving
P47/Pleckstrin Polyklonale Antilichaam, HRP-vervoeging Beschikbaar in 100 µL. Bestel eenvoudig online met snelle levering.
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