P53 Antilichaam

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277) .

7157

P04637

Human, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human p53 (NP_000537.3) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction, Transcription

Affinity purification

MCF7

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 53kDa

IgG

TP53

U-251MG

Tumor protein p53

Homo sapiens

TP53, P53, BCC7, LFS1, TRP53

WB, IHC, IF, ChIP

Liquid